I’m interested in giving him his first handgun. He’s 20 and lives in SC. I live in FL if that matters… Can I give him 1?
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Probably not. From what I understand about SC Law, you need to be 21 to purchase / own a handgun in SC. But (disclaimer) I’m not a lawyer, so don’t consider this to be an official answer 
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@Chris269 Welcome to our community, we are glad to have you. 
As Patrick said that pesky 21 rule comes in play.
You can read both states laws and rules here.k
Summary of Florida Gun Laws
Florida is a shall-issue state with concealed weapons licenses issued at the state level by the Florida Department of Agriculture and Consumer Services (FDACS).
There is no license, background check or firearms registration required when buying a handgun from a private individual. Buyers must be at least 21 years old to purchase any firearm and although several counties have enacted ordinances establishing waiting periods for some purchases from non-licensed sellers (often at gun shows), Florida Concealed Weapons License (CWL) holders are exempt.
Summary of South Carolina Gun Laws
South Carolina is a shall-issue state with concealed weapons permits issued at the state level by the South Carolina Law Enforcement Division (SLED).
There is no permit, background check or firearms registration required when buying a handgun from a private individual.
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Welcome Chris269.
Bill of sale receipt:
Per USCCA site,
“Private firearms transfers are not subject to a background check requirement, although federal and state purchaser prohibitions, including age restrictions, still apply. It is recommended that you retain any sales receipts to prove ownership of the gun.”
https://www.usconcealedcarry.com/resources/ccw_reciprocity_map/sc-gun-laws/
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To add to the above information. Along with your nephew needing to be 21 to receive the handgun per SC law you will also need to do the transfer through a FFL dealer since you both reside in different States.
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Welcome
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