This is presumably .45 Colt, not .45 Auto. If James Arness is biting down on a .45 ACP, they must have had continuity problems with that episode. Or maybe you were thinking of the other Matt Dillon — did he have another Doc Adams? That still seems like it would be a continuity issue.
I’ll ask Milburn Stone next time I see him. He seems to know a lot about these things.
How about 9 mm Kurz, 9 X 18, 9mm Makarov, 9 X 21, 9 mm Largo too. .38 Super and .38 ACP. .45 GAP too. I know 1 is obsolete, but it really gets crazy as far as calibers. Bottom line, know your firearm and what to feed it.