I can’t usually do 100 rounds with my G43. My hand-size & grip leads to the ring on my ring finger landing exactly on the knuckle of the opposite hand and after a few dozen rounds that knuckle is bruised.
It is likely just more practice needed. Keep in mind the difference in sight radius between a G43 and something like a G17 is pretty significant. So even if you do everything right, there will be some inherent accuracy reduction and that just gets more noticeable the farther you go out.
If you need to shoot the flea off a dogs back at 25yards the G43 is probably not the right tool. So you have to also consider (and everyone is different) what is your acceptable accuracy at a given range.
I am cheap, so I frequently use paper plates as my targets Is hitting that plate at 7yards a must? How about 15yards? How about 25yards? How about 50yards? For me those answers are yes, yes, hopefully, and lol. YMMV
I wont speak for @TexasEskimo but for me, lots of practice. And getting used to a broader sight picture. Realizing that for precision it will take a little longer on each shot to be precise. And maybe realizing that a center-of-mass hit at longer distances is “good enough”.