The 10mm is hard on guns and hands. Have a bud with a Colt Delta Elite that the front rails are fractured on, mebby 5,000 rnds. It’s also insanely expensive to shoot. For weight vs. potential I’d think 40 S&W or .45 ACP in whatever poly frame you prefer. If you are worried about four legged critters I’d run the highest velocity ammo(lightest boolet weight), for two legged critters the heaviest bullet.
Cheers,
Craig6