I am an NRA Basic Pistol Instructor and USCCA affiliate instructor. I mostly work with local churches because I also work with FEMA and they have an excellent program for strengthening church safety.
I have had students come to the course with weak or compromised wrists. Rather than tell them they are “just out of luck” or have them rely on someone else for protection, I turn to the .22lr.
Walther, Glock, Ruger, and even Smith & Wesson all have their signature pistols chambered for .22lr. Visually, you cannot easily see the difference between the Q5 Match in 9mm and its .22lr counterpart. The same for the Glock 19 and the Glock 44. This is also true with the other manufacturers. I just cannot see a bad guy taking the time to determine if that S&W EZ pointed at his chest is in .22lr or 9mm.
I first picked up a Colt Gold Cup 1911 in .22lr that was the mirror image of my Colt Gold Cup .45acp so that I could practice a whole lot more for a whole lot less $$$. Since that time, I have done the same with my G19 and G44. I get a ton more range time shooting .22lr than either 9mm, .45acp or especially 10mm. Even CMMG has a .22lr conversion for my Daniel Defense Mk4 in 5.56 mm!
Copper’s rules for surviving gun fights makes mention that you must always bring a gun to a gun fight. Other Big Name Instructors have said that 10 hits with a .22lr are infinitely better than 10 misses in any other caliber.
If a .22lr is all you can handle, and you shoot very well with it and are extremely confident in your abilities, then I say “Welcome to the gun fight!”
Unless of course you are shooting bear. In that case, “your out of luck!”